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Role of vif in supporting viral replication

来源:本站整理  发布时间:2010/11/24 10:05:11

Role of vif in supporting viral replication. Some recent publications have highlighted a new and important role for vif in supporting viral replication. Vif-deficient HIV-1 isolates do not replicate in CD4+ T-cells, some T-cell lines (“non-permissive cells”), or in macrophages. Vif-deficient isolates are able to enter a target cell and initiate reverse transcription, but synthesis of proviral DNA remains incomplete. In vitro fusion of “permissive” and “non-permissive” cells leads to a “non-permissive” phenotype, suggesting that the replication of HIV depends on the presence or absence of a cellular inhibitor. This endogenous inhibitory factor was recently identified as APOBEC3G (apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G). APOBEC3G belongs to a family of intracellular enzymes that specifically deaminate cytosine to uracil in mRNA or DNA, resulting in an accumulation of G-to-A mutations that lead to degradation of viral DNA. By forming a complex with APOBEC3G, vif blocks the inhibitory activity of APOBEC3G .

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